Feline corona virus (FIP) ELISA

Feline corona virus (FIP) ELISA

Species:  Feline

Specimen: Serum

Collection protocol: Red top or gel tube

Special handling/shipping requirements: Standard

General information about the disease:

FIP is a coronavirus infection of cats of any age but most prevalent among cats <3 years (particularly 4-16 months). Purebred male cats appear to be predisposed. Mortality is high once clinical signs appear. FIP virus arises through specific mutations in a common, non-pathogenic, enteric feline coronavirus ubiquitous in cats. Most kittens are exposed to coronavirus by nine weeks of age but only a small proportion of cats develop FIP related to genetic susceptibility, age of first infection, and stressors at the same time as infection.

General information about when this test is indicated:

The ELISA detects but does not differentiate between enteric coronavirus and FIP virus antibody titres. A positive titre result needs to be interpreted in conjunction with clinical signs and other related tests as detailed below. A combination of clinical signs and test results needs to be considered to confirm a diagnosis.

Comparison with other related tests:

Blood tests: common abnormalities include chronic non-regenerative anaemia, neutrophilia and lymphopaenia, elevated globulin and decreased albumin.

Effusions: fluid in the abdomen or pleura are suggestive of FIP and are protein rich exudates with moderate cellularity, often viscous and yellow-tinged. The albumin to globulin (A:G) ratio can also be measured in effusions as well as feline enteric coronavirus/FIP virus titre.

Intraocular and neurological signs: uveitis, meningitis and/or meningomyelitis are highly suggestive of FIP in young cats

Histopathology: characteristic pathological lesions are seen on histopathology of affected tissues (by biopsy or necropsy collection) and immunohistochemical detection of the virus within these lesions is currently considered the diagnostic gold standard.